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Updated: Aug 18, 2025
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Cu-Catalyzed Ullmann-Type Double C-N Coupling Approach to 5-Aryl-5H-indolizino[3,2-b]indoles
1College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Republic of Korea.
Abstract:
A modular approach to a polyfunctionalized 5H-indolizino[3,2-b]indole, an indolizine-indole fused system, was achieved from readily available pyridine-2-acetonitrile, 2-bromobenzaldehyde, and TMSCN via the strategic combination of a one-pot three-component assembly and Cu-catalyzed Ullmann-type double C-N coupling reactions through which five new bonds (two C-C and three C-N) were formed in two steps.
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