Caries Management-The Role of Surface Interactions in De- and Remineralization-Processes

Area of Science:

• Oral biology
• Dental research
• Biomineralization

Background:

• Bioadhesion and surface interactions on enamel are critical for dental caries and erosion.
• Salivary proteins in the pellicle and within early lesions impact demineralization and remineralization.
• Limited understanding exists regarding protein structures in initial caries and erosion.

Purpose of the Study:

• To review current knowledge on tooth surface-oral fluid interactions.
• To understand the role of proteinaceous structures in dental hard tissues.
• To identify needs for novel preventive agents against caries and erosion.

Main Methods:

• Literature review of existing research on dental bioadhesion and protein interactions.
• Analysis of the role of salivary proteins in demineralization and remineralization processes.
• Synthesis of current understanding of oral surface chemistry and biology.

Main Results:

• Protein layers on dental hard tissues can either prevent or worsen demineralization.
• Proteins within initial carious or erosive lesions may significantly impede remineralization.
• These proteins can restrict ion entry into developing lesions.

Conclusions:

• Organic-inorganic surface interactions are crucial for tooth de- and remineralization.
• Knowledge gaps persist regarding these clinically relevant phenomena.
• Intensive research is required to advance preventive dentistry strategies.