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Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
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MRI Contrast Agents in Glycobiology.
Carlos F G C Geraldes1,2, Joop A Peters3
1Department of Life Sciences and Coimbra Chemistry Centre, Faculty of Science and Technology, University of Coimbra, 3000-393 Coimbra, Portugal.
Molecules (Basel, Switzerland)
|December 11, 2022
Summary
This review explores magnetic resonance imaging probes for visualizing glycoprotein interactions. These probes use carbohydrates as targeting vectors or targets for medical diagnosis and drug design.
Area of Science:
- Biochemistry and Molecular Biology
- Medical Imaging
- Glycobiology
Background:
- Glycoprotein-mediated molecular recognition is crucial in biological processes.
- Visualizing these interactions and sugar expression poses challenges for medical diagnosis, therapy monitoring, and drug design.
Purpose of the Study:
- To review the literature on developing and validating magnetic resonance imaging (MRI) probes.
- To explore the use of carbohydrates as targeting vectors or targets in MRI probes.
Main Methods:
- Literature review of existing research on MRI probes for carbohydrate interactions.
- Analysis of carbohydrate-based targeting vectors (e.g., lectins) and targets (e.g., selectins, hyaluronic acid).
Main Results:
- Development of MRI probes utilizing carbohydrates for enhanced visualization.
- Identification of key carbohydrate targets and lectin-based targeting vectors for probe design.
Conclusions:
- MRI probes offer a promising approach for visualizing glycoprotein-mediated interactions.
- These probes have significant potential in medical diagnosis, therapy monitoring, and drug development.
Keywords:
asialoglycoprotein receptorbiomarkersdiagnostic agentsglycohemoglobinlectinsmagnetic resonance contrast agentsselectinssialic acidtheranosticsMore Related Videos
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