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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Updated: Jun 4, 2025

Manganese Oxide Nanoparticle Synthesis by Thermal Decomposition of ManganeseII Acetylacetonate

Manganese Oxide Nanoparticle Synthesis by Thermal Decomposition of ManganeseII Acetylacetonate

Published on: June 18, 2020

Manganese Oxide Nanoparticles for MRI-Based Multimodal Imaging and Theranostics.

Carlos F G C Geraldes^1,2

¹Department of Life Sciences and Coimbra Chemistry Center-Institute of Molecular Sciences (CQC-IMS), Faculty of Science and Technology, University of Coimbra, 3004-531 Coimbra, Portugal.

Molecules (Basel, Switzerland)

|December 17, 2024

Summary

Manganese oxide nanoparticles offer a safer, effective alternative to gadolinium contrast agents for MRI. These manganese-based nanostructures show promise for advanced diagnostics and theranostics.

Keywords:

contrast agents functionalized nanoparticles magnetic resonance imaging manganese oxides multimodal imaging theranostics

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Published on: November 20, 2018

Area of Science:

Nanotechnology
Medical Imaging
Materials Science

Background:

Gadolinium-based contrast agents face scrutiny due to toxicity concerns.
Manganese-based MRI contrast agents are emerging as a promising alternative.
Nanoparticle formulations offer enhanced properties for in vivo applications.

Purpose of the Study:

To review manganese oxide nanoparticles (MnₓOᵧ NPs) for MRI and theranostic applications.
To discuss MnₓOᵧ NPs in +2, +3, and +4 oxidation states.
To highlight advantages over gadolinium-based nanosystems.

Main Methods:

Review of recent literature on MnₓOᵧ NPs for MRI.
Analysis of magnetic properties, biocompatibility, and toxicity profiles.
Discussion of selected examples from the past decade.

Main Results:

MnₓOᵧ NPs exhibit favorable magnetic properties and good biocompatibility.
These nanoparticles demonstrate an improved toxicity profile compared to Gd(III)-based systems.
Mn ions offer advantages for next-generation MRI and theranostic contrast agents.

Conclusions:

Manganese oxide nanoparticles are a viable alternative to gadolinium contrast agents.
Their potential for enhancing relaxivity and MRI contrast is significant.
MnₓOᵧ NPs represent a promising direction for advanced diagnostics and theranostics.