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ACE-Vitamin Index and Risk of Glaucoma: The SUN Project.
Javier Moreno-Montañés1,2, Elsa Gándara1, Laura Moreno-Galarraga2,3
1Department of Ophthalmology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Nutrients
|December 11, 2022
Summary
Consuming vitamins A, C, and E together, but not individually, may reduce glaucoma risk. This combined vitamin intake was linked to a lower incidence of glaucoma in a large study.
Area of Science:
- Ophthalmology
- Nutritional Science
- Preventive Medicine
Background:
- Conflicting evidence exists on antioxidant intake and glaucoma risk.
- The SUN Project investigated the role of specific vitamin consumption in glaucoma incidence.
Purpose of the Study:
- To evaluate the combined effect of vitamins A, C, and E on glaucoma incidence.
- To determine if individual or combined vitamin intake influences glaucoma risk.
Main Methods:
- 18,669 participants were followed for a mean of 11.5 years.
- An ACE-Vitamin Index was created from dietary and supplement data.
- Glaucoma incidence was assessed via validated self-reported questionnaires and analyzed using Cox regression.
Main Results:
- A total of 251 glaucoma cases were identified.
- Higher consumption of the ACE-Vitamin Index was associated with a reduced risk of glaucoma (aHR = 0.73).
- This protective effect was more pronounced in men and individuals aged 55 and older.
Conclusions:
- Individual intake of vitamins A, C, or E did not show a significant protective effect against glaucoma.
- Combined consumption of vitamins A, C, and E together is associated with a lower risk of developing glaucoma.
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