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Updated: Aug 17, 2025

Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides
Published on: July 14, 2015
Non-porous silica support covalent organic frameworks as stationary phases for liquid chromatography
Meichao Xie1,2, Kaijun Quan2, Hui Li2
1Department of Chemistry, Research Center for Analytical Sciences, College of Sciences, Northeastern University, Shenyang 110819, China. yuyl@mail.neu.edu.cn.
Abstract:
A new strategy using non-porous silica (NPS) spheres as the support and covalent organic frameworks (COFs) as the porous functional shell for liquid chromatography was developed to ensure the independent effect of the COFs on the separation. As a proof of concept, NPS@TPB-DMTP was prepared for liquid chromatographic analysis using 1,3,5-tris(4-aminophenyl)benzene (TPB) and 2,5-dimethoxy-1,4-benzenedicarboxaldehyde (DMTP) as monomers by in situ polymerisation on the surface of NPS. It is a new way of developing COF-based stationary phases, which will be helpful in understanding what effect the COFs will have on separation.
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