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Updated: Aug 17, 2025
06:53
Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
12.6K
[Current Management of Basal Cell Carcinoma]
Manuel Krieter1, Erwin Schultz1
1Universitätsklinik für Dermatologie, Paracelsus Medizinische Privatuniversität Nürnberg, Nürnberg, Deutschland.
Laryngo- Rhino- Otologie
|December 13, 2022
Summary
Basal cell carcinoma (BCC) management requires risk stratification due to tumor heterogeneity. Surgical procedures remain the gold standard, with newer therapies like hedgehog inhibitors and cemiplimab offering options for advanced cases.
Area of Science:
- Dermatology
- Oncology
- Cancer Research
Context:
- Basal cell carcinoma (BCC) is the most prevalent human tumor, with rising incidence.
- Tumor heterogeneity necessitates a nuanced approach beyond simple subtype classification.
- Risk stratification is crucial for guiding diagnosis and treatment decisions.
Purpose:
- To present the current standards in basal cell carcinoma diagnosis and treatment.
- To outline procedures for effective clinical management based on evidence.
- To inform clinical practice regarding evolving therapeutic options.
Summary:
- Micrographically controlled surgery is the gold standard for BCC treatment.
- Radiotherapy, topical therapies (photodynamic therapy, cryotherapy, 5-fluorouracil, imiquimod), hedgehog inhibitors, and cemiplimab are alternative or advanced treatment options.
- Risk stratification guides the selection of appropriate diagnostic and therapeutic strategies.
Impact:
- Structured assessment and tailored therapy improve outcomes for BCC patients.
- Advanced and metastatic BCC are manageable with current therapeutic advancements.
- Long-term therapies and novel agents like cemiplimab offer new hope and improved quality of life.
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