Two unusual novel iridoid glycosides from Cornus officinalis fruit and their biological activities

Two unusual novel iridoid glycosides, cornsecoside A (1) and cornsecoside B (2), were isolated from a 40% ethanol elution fraction of a 50% ethanol extract of Cornus officinalis fruit. Their structures were determined by spectroscopic data analysis combined with hydrolysis and ECD spectroscopy. In addition, compounds 1 and 2 exhibited cytotoxic activity against Bel-7402 cells with IC₅₀ values of 8.12 and 9.31 µM, and were neuroprotective against H₂O₂-induced SH-SY5Y cell injure at a concentration of 10 µM.