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Ring domains are essential for GATOR2-dependent mTORC1 activation.

Cong Jiang1, Xiaoming Dai1, Shaohui He2

  • 1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

Molecular Cell
|December 17, 2022
PubMed
Summary

The Ring domains of the GATOR2 complex are crucial for sensing amino acids and activating mTORC1 signaling. Disruption impairs nutrient sensing, leading to severe growth defects and embryonic lethality in mice.

Keywords:
Gator1Gator2NPRL2SestrinWDR24amino acid sensingmTORubiquitination

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