Related Experiment Video

Updated: Aug 16, 2025

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
08:12

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels

Published on: May 26, 2023

1.7K

Long-term evaluation of TTK Chitra™ heart valve prosthesis - a retrospective-prospective cohort study

Praveen Kerala Varma1, Maniyal Vijayakumar2, Gopichettipalayam Subbaratnam Bhuvaneshwar3

  • 1Department of Cardiovascular and Thoracic Surgery, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham (Amrita University), Kochi, India.

Indian Journal of Thoracic and Cardiovascular Surgery
|December 19, 2022
PubMed

Insights

Long-term follow-up of the TTK Chitra™ heart valve shows good survival rates and low adverse event incidence. This study confirms the continued safety and performance of the TTKCHV at 15 years.

Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Surgical Innovation

Background:

  • The TTK Chitra™ heart valve (TTKCHV) has a significant implantation history (>140,000).
  • Limited long-term clinical data has been published for the TTKCHV.
  • This study addresses the need for comprehensive long-term outcome data.

Purpose of the Study:

  • To evaluate the long-term safety and performance of the TTK Chitra™ heart valve.
  • To report actuarial survival and freedom from valve-related morbidity and mortality.
  • To assess the incidence of adverse events such as structural failure, thrombosis, thromboembolism, and hemorrhage.

Main Methods:

  • Prospective follow-up of 476 patients who received TTKCHV implants between January 2006 and December 2018.
  • Cohort included patients undergoing aortic valve replacement (AVR), double valve replacement (DVR), and mitral valve replacement (MVR).
  • Total follow-up duration of 4079 patient-years with 96% completeness.

Main Results:

  • 15-year actuarial survival rates: 82.3% (AVR), 60.7% (MVR), 52.2% (DVR).
  • 15-year freedom from valve-related mortality/morbidity: 73.8% (AVR), 64.8% (MVR), 61.9% (DVR).
  • Low linearized rates of adverse events, including one structural failure, low valve thrombosis, and manageable rates of thromboembolism and major hemorrhage, lower than previously reported.

Conclusions:

  • The TTK Chitra™ heart valve demonstrates continued safety and effective performance over a 15-year period.
  • The study provides robust long-term data supporting the TTKCHV's clinical utility.
  • Findings suggest favorable outcomes compared to earlier published data.
Abstract

Keywords:
Long-term outcomesMechanical heart valveRheumatic heart diseaseTTK Chitra™ heart valve (TTKCHV)Tilting disc valve

More Related Videos

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure07:41

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure

Published on: February 8, 2022

3.8K
Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement14:14

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

14.1K

Related Concept Videos

Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
36
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
31
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
29