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Continuous Positive Linear Association between the Monocyte to High-Density Lipoprotein Cholesterol Ratio and

Yaqing Zhou1, Haijun Dan1, Long Bai2

  • 1Department of Physical Examination Center, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China.

International Journal of Hypertension
|December 19, 2022
PubMed

Insights

The monocyte to high-density lipoprotein cholesterol ratio (MHR) is positively associated with hypertension. This inflammatory indicator shows a continuous linear relationship with hypertension risk in health examination populations.

Area of Science:

  • Cardiology
  • Biochemistry
  • Public Health

Background:

  • Hypertension is a significant global health concern.
  • Inflammation is increasingly recognized as a contributing factor to hypertension development.
  • The monocyte to high-density lipoprotein cholesterol ratio (MHR) is a novel inflammatory marker requiring further investigation in relation to hypertension.

Purpose of the Study:

  • To investigate the association between the monocyte to high-density lipoprotein cholesterol ratio (MHR) and hypertension.
  • To determine if MHR can serve as a predictive indicator for hypertension risk.

Main Methods:

  • A cross-sectional study was conducted with 6632 participants from a health examination center.
  • Data collected included demographic, clinical, blood pressure, and biochemical measurements, including MHR.
  • Statistical analyses involved univariate, multivariate logistic regression, smooth function analysis, and subgroup analysis to examine the MHR-hypertension relationship.

Main Results:

  • A significant positive association was observed between MHR and hypertension, even after adjusting for potential confounders (OR = 1.07, 95% CI: 1.05-1.10).
  • Generalized additive models confirmed a continuous positive linear association between MHR and hypertension across the studied population.
  • Subgroup analyses indicated consistent findings across different demographic and clinical groups, suggesting a robust association.

Conclusions:

  • The study demonstrates a continuous positive linear association between the monocyte to high-density lipoprotein cholesterol ratio (MHR) and hypertension.
  • Elevated MHR may indicate an increased risk of developing hypertension.
  • MHR warrants consideration as a potential biomarker for hypertension risk assessment in clinical settings.
Abstract

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