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A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model
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Serum Collagen Triple Helix Repeat Containing-1 Levels are Related to Radiological Affection and Disease Activity in

Eman Mostafa Nassef1, Hemmat Ahmed Elabd2, Hala Mohamed Elzomor2

  • 1Internal Medicine Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.

Open Access Rheumatology : Research and Reviews
|December 19, 2022
PubMed

Insights

Collagen triple helix repeat containing-1 (CTHRC1) levels are elevated in rheumatoid arthritis (RA) patients. Higher CTHRC1 indicates increased disease activity and radiological damage in RA.

Area of Science:

  • Rheumatology
  • Immunology
  • Biochemistry

Background:

  • Rheumatoid arthritis (RA) is a prevalent systemic inflammatory condition.
  • Collagen triple helix repeat containing-1 (CTHRC1) is a protein known to modulate collagen deposition.
  • Understanding CTHRC1's role in RA pathogenesis is crucial for potential therapeutic strategies.

Purpose of the Study:

  • To quantify serum CTHRC1 levels in patients with rheumatoid arthritis.
  • To investigate the correlation between CTHRC1 levels and clinical, laboratory, and radiological markers of RA.
  • To explore CTHRC1 as a potential biomarker for RA disease severity.

Main Methods:

  • Serum CTHRC1 levels were measured using Enzyme-Linked Immunosorbent Assay (ELISA).
  • The study included 60 adult RA patients and 60 controls (osteoarthritis, reactive arthritis, healthy).
  • Disease activity was assessed via DAS28-CRP, and radiological damage using the Simple Erosion Narrowing Score (SENS).

Main Results:

  • RA patients exhibited significantly higher serum CTHRC1 levels compared to all control groups.
  • Elevated CTHRC1 levels correlated positively with higher disease activity scores (DAS28-CRP).
  • Increased CTHRC1 was significantly associated with greater radiological damage (SENS) in RA patients.

Conclusions:

  • Serum CTHRC1 levels are significantly elevated in rheumatoid arthritis patients.
  • CTHRC1 levels are directly related to disease severity and radiological joint affection in RA.
  • CTHRC1 may serve as a valuable biomarker for assessing RA progression and activity.
Abstract

Keywords:
CTHRC1osteoarthritisrheumatoid arthritis

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