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The Independent Association Between Age and Serum Cholesterol Levels in Patients with Familial Hypercholesterolemia

Jinchun He1,2, Yan Wu1, Yaodong Wang3

  • 1Department of Laboratory Medicine, The First Hospital of Lanzhou University, The First School of Clinical Medicine, Lanzhou University, Lanzhou 730030, Gansu, China.

Discovery Medicine
|December 19, 2022
PubMed

Insights

Age significantly impacts total cholesterol (TC) in familial hypercholesterolemia (FH) patients. Early screening and intervention are crucial for managing cardiovascular disease (CVD) risk in FH.

Area of Science:

  • Cardiology
  • Genetics
  • Metabolic Disorders

Background:

  • Familial hypercholesterolemia (FH) is a genetic disorder leading to high cholesterol.
  • Age and serum total cholesterol (TC) are known cardiovascular disease (CVD) risk factors.
  • The specific relationship between age and TC in FH patients requires further investigation.

Purpose of the Study:

  • To investigate the correlation between age and serum total cholesterol (TC) levels in patients diagnosed with familial hypercholesterolemia (FH).

Main Methods:

  • Recruited 103 FH patients and 106 non-FH controls between 2004 and 2017.
  • Employed Spearman, partial correlation, multiple linear, and logistic regression analyses.
  • Evaluated the relationship between age and TC, controlling for other variables.

Main Results:

  • FH patients exhibited significantly higher TC, LDL-C, HDL-C, Lp(a), and non-HDL-C compared to controls.
  • Serum TC levels were significantly higher in FH patients aged 50 years and older.
  • Age demonstrated a significant positive correlation with serum TC in FH patients (p < 0.001), but not in controls.

Conclusions:

  • Age is an independent factor influencing serum TC levels in individuals with FH.
  • Highlights the necessity for early screening and timely intervention strategies in FH management.
  • Emphasizes the importance of considering age in risk stratification for cardiovascular events in FH.
Abstract

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