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Tuning chitosan's chemical structure for enhanced biological functions
Mortaza Aghbashlo1, Hamid Amiri2, Seyed Masoud Moosavi Basri3
1Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences, Beijing 100081, PR China; Department of Mechanical Engineering of Agricultural Machinery, Faculty of Agricultural Engineering and Technology, College of Agriculture and Natural Resources, University of Tehran, Karaj, Iran.
Trends in Biotechnology
|December 19, 2022
Summary
This review explores enzymes and cell factories for preparing chitosan oligosaccharides (COSs). It highlights how chitosan
Area of Science:
- Biomaterials Science
- Biochemistry
- Biotechnology
Background:
- Chitosan, an amino polysaccharide from crustaceans, exhibits biological activities influenced by molecular weight (MW), degree of deacetylation (DD), and acetylation pattern (AP).
- Structural homogeneity of chitosan is crucial for its efficacy in advanced biomaterials.
Purpose of the Study:
- To review emerging enzymatic and cell-based methods for in vitro and in vivo preparation of chitosan oligosaccharides (COSs).
- To focus on advancements in analyzing the acetylation pattern (AP) and structurally modifying chitosan to optimize its functions.
Main Methods:
- Review of literature on enzymatic and cell factory-based production of COSs.
- Analysis of methods for determining chitosan's acetylation pattern (AP).
- Examination of strategies for chitosan structural modification.
Main Results:
- Identification of key enzymes and cell factories for chitosan oligosaccharide (COS) preparation.
- Summary of current analytical techniques for chitosan's acetylation pattern (AP).
- Overview of methods to tune chitosan's functional properties through structural modification.
Conclusions:
- Mapping current knowledge on chitosan's in vitro and in vivo activity relative to its MW and AP.
- This work provides a foundation for future research into chitosan-based biomaterials and therapeutics.
