Design, Synthesis, Insecticidal Activities and Molecular Docking of Sulfonamide Derivatives Containing Propargyloxy...

Area of Science:

• Agricultural Chemistry
• Organic Chemistry
• Insecticide Development

Background:

• Natural products are a key source for discovering new, highly active pesticide molecules.
• Celangulin V shows significant insecticidal activity against Mythimna separate by targeting the V-ATPase H subunit.

Purpose of the Study:

• To synthesize and evaluate novel sulfonamide derivatives as potential insecticides.
• To identify cost-effective and highly efficient compounds targeting the V-ATPase H subunit of Mythimna separate.

Main Methods:

• Systematic synthesis of thirty-seven sulfonamide derivatives with propargyloxy or pyridine groups.
• Bioactivity assays were conducted on third-instar larvae of Mythimna separate.
• Molecular docking experiments were performed to predict the binding mechanism.

Main Results:

• Compounds A2-A4 and A6-A7 displayed enhanced insecticidal activity against M. separate larvae.
• The LC50 values for these compounds ranged from 2.48 to 3.54 mg/mL, outperforming Celangulin V (LC50 = 18.1 mg/mL).
• Molecular docking suggested these derivatives interact with the V-ATPase H subunit.

Conclusions:

• The synthesized sulfonamide derivatives show significant potential as novel insecticides.
• These compounds offer a promising foundation for developing new pest control agents targeting the V-ATPase H subunit.
• Further research into these derivatives could lead to more efficient and selective insecticides.