Experimental demonstration of ultrahigh sensitivity Talbot-Lau interferometer for low dose mammography

Objective. Even though the techniques used for breast cancer identification have advanced over the years, current mammography based on x-rays absorption, the 'gold standard' screening test at present, still has some shortcomings as concerns sensitivity and specificity to early-stage cancers, due to poor differentiation between tumor and normal tissues, especially in the case of the dense breasts. We investigate a possible additional technique for breast cancer detection with higher sensitivity and low dose, x-ray phase-contrast or refraction-based imaging with ultrahigh angular sensitivity grating interferometers, having several meters length.Approach.Towards this goal, we built and tested on a mammography phantom, a table-top laboratory setup based on a 5.7 m long Talbot-Lau interferometer with angular sensitivity better than 1μrad. We used a high-power x-ray tungsten anode tube with a 400μm focal spot, operated at 40 kVp and 15 mA with a 2 mm aluminum filter.Main results.The results reported in our paper confirm the ultrahigh sensitivity and dose economy possible with our setup. The visibility of objects simulating cancerous formations is strongly increased in the refraction images over the attenuation ones, even at a low dose of 0.32 mGy. Notably, the smallest fiber of 400μm diameter and calcifications specs of 160μm in diameter are detected, even though the spatial resolution at the object of our magnification M ∼ 2 setup with a 400μm source spot is only ∼250μm.Significance.Our experiments on a mammography phantom illustrate the capabilities of the proposed technique and can open the way toward low-dose interferometric mammography.