[Comments on reversible nonhormonal contraception in the male]

The development of substances that could be employed as male contraceptives would be of worldwide importance. As yet, however, it has not proved possible to find a substance which provides reliable contraception during use, whose effects are reversible following discontinuation, and which has minimal side-effects. Furthermore, the possibility of mutagenic effects and adverse effects on libido or sexual potency must be excluded and systemic application must be possible. The drugs gossypol, alpha-chlorohydrin and hexose derivates, which are presented in detail in this article, partly fulfil these requirements but are still a long way from representing an ideal compound for use as a male contraceptive. However, studies of these drugs may indicate ways of achieving the ultimate goal. The drugs showed interesting properties, which suggest that they may be used for purposes other than male contraception.