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Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems
Published on: May 2, 2025
489
Nanoclays for wound management applications
Filipa Mascarenhas-Melo1,2, Diana Peixoto3,4, Carolina Aleixo3
1Department of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Azinhaga Sta. Comba, 3000-548, Coimbra, Portugal. filipamelo@ff.uc.pt.
Drug Delivery and Translational Research
|December 21, 2022
Summary
Nanoclays, nanoscale aluminosilicates, enhance wound healing by promoting tissue repair and reducing inflammation. They can be used alone or with therapeutic molecules to improve treatments for various skin lesions and wounds.
Area of Science:
- Materials Science
- Biomedical Engineering
- Nanotechnology
Background:
- Nanotechnology offers novel approaches to wound healing management.
- Nanoclays, nanoscale aluminosilicates, possess intrinsic properties beneficial for healing.
- These properties include hemostatic, anti-inflammatory, angiogenic, and re-epithelialization effects.
Purpose of the Study:
- To review the application of nanoclays in treating skin lesions, post-surgical wounds, burn wounds, and chronic ulcers.
- To explore nanoclays as vehicles for therapeutic molecules and as standalone treatments.
- To analyze the structural influence on nanoclay properties and wound healing efficacy.
Main Methods:
- Systematic literature search of major scientific databases (PubMed, ScienceDirect, Scopus, Web of Science, Google Scholar).
- Keyword refinement for information selection.
- Comparative analysis of different nanoclays, focusing on phyllosilicates and their structural impact on surface area and loading capacity.
Main Results:
- Nanoclays, particularly non-planar hydrous phyllosilicates, show significant potential in wound healing.
- Nanocomposites can be incorporated into polymers to create adjustable wound dressings like gels, biofilms, and scaffolds.
- Nanoclays enhance mechanical strength, thermal stability, and viscosity of wound materials, control drug release, and improve skin bioavailability.
Conclusions:
- Nanoclays are promising for wound healing due to their inherent properties and ability to enhance therapeutic delivery.
- Their incorporation into wound dressing materials improves physical and biological characteristics.
- Further in vivo toxicity studies are necessary to fully establish their safety and efficacy.
