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HLA expression on human germinal cells.

M Kurpisz1, N Fernandez, M Witt

  • 1Institute of Human Genetics, Polish Academy of Science, Poznan.

Journal of Immunogenetics
|February 1, 1987
PubMed
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Human leukocyte antigen (HLA) class I and II antigens were detected on sperm cells in some healthy men and infertile patients. Expression varied over time in healthy individuals, but was present in a subset of infertile men.

Area of Science:

  • Immunology
  • Reproductive Biology
  • Genetics

Background:

  • Human leukocyte antigens (HLA) are crucial for immune response.
  • Their presence on spermatozoa is not fully understood, particularly in relation to male infertility.

Purpose of the Study:

  • To investigate the expression of HLA class I and II antigens on ejaculated human sperm cells.
  • To compare antigen expression between healthy men and infertile patients.

Main Methods:

  • Testing of seminal plasma cells from 46 healthy men and 48 infertile patients.
  • Utilized complement-mediated cytotoxicity, cell-binding radioimmunoassay (CB-RIA), and ELISA with monoclonal antibodies (mAbs).

Main Results:

  • 4 out of 46 healthy men showed positive expression of HLA class I and II antigens on sperm; results varied upon re-testing.

Related Experiment Videos

  • 7 out of 48 infertile patients exhibited positive expression of HLA class I and II antigens on sperm.
  • Samples confirmed the presence of mature and immature sperm without contaminating cells.

    • Conclusions:

    • HLA class I and II antigens can be expressed on human spermatozoa.
    • Variable expression in healthy individuals suggests dynamic cellular changes.
    • Presence of these antigens in a subset of infertile men warrants further investigation into their role in male fertility.