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Global Hemostasis Potential in COVID-19 Positive Patients Performed on St-Genesia Show Hypercoagulable State

Beverly Buffart1, Anne Demulder1, Marco Fangazio1

  • 1Department of Hematology, LHUB-ULB, Université Libre de Bruxelles (ULB), 1020 Brussels, Belgium.

Journal of Clinical Medicine
|December 23, 2022
PubMed

Insights

COVID-19 patients exhibit hypercoagulability, indicated by altered thrombin generation test (TGT) profiles. This hypercoagulable state is more pronounced in severe COVID-19 cases, suggesting TGT

Area of Science:

  • Hematology
  • Infectious Diseases
  • Clinical Pathology

Background:

  • COVID-19 complications frequently involve thromboembolisms, which are difficult to predict with standard laboratory tests.
  • There is a need for reliable biomarkers to assess hypercoagulability and thrombotic risk in COVID-19 patients.

Purpose of the Study:

  • To evaluate the thrombin generation test (TGT) as a predictor of hypercoagulability and thrombotic risk in COVID-19 patients.

Main Methods:

  • Retrospective analysis of routine blood tests and TGT in 52 patients (26 COVID-19 positive, 26 negative).
  • COVID-19 patients were stratified into severe (n=11) and non-severe (n=15) groups.
  • TGT was performed with and without thrombomodulin (TM) addition.

Main Results:

  • COVID-19 patients showed altered lymphocyte, monocyte, and basophil counts, and elevated LDH, AST, and ALT.
  • TGT revealed significant differences in thrombin peak heights between COVID-19 positive and negative groups.
  • Thrombomodulin addition to TGT showed increased peak height, Endogenous Thrombin Potential (ETP), and velocity index in COVID-19 patients, with greater changes in severe cases.
  • Reduced ETP inhibition percentage was observed in COVID-19 patients, particularly in severe cases.

Conclusions:

  • All COVID-19 patients demonstrate a hypercoagulable TGT profile.
  • The hypercoagulability is more pronounced in patients with severe COVID-19.
  • TGT may serve as a valuable tool for assessing thrombotic risk in COVID-19.
Abstract

Keywords:
COVID-19hypercoagulable statethrombin generationthromboembolic riskthrombomodulin

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