Facile Green Synthesis of Ni(OH)₂@Mn₃O₄ Cactus-Type Nanocomposite: Characterization and Cytotoxicity Properties

In the present work, the facile eco-friendly synthesis and evaluation of the anti-tumor activity of Ni(OH)₂@Mn₃O₄ nanocomposite were carried out. The synthesis of Ni(OH)₂@Mn₃O₄ nanocomposite from chia-seed extract was mediated by sonication. The obtained materials were characterized by different spectroscopic techniques such as transmission electron microscopy (TEM), scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), ultraviolet-visible (UV-Vis), and Fourier transform infrared (FT-IR) spectroscopies. The results of XRD, SEM, EDS, TEM, FT-IR, and UV-Vis analysis indicate the successful manufacturing of a crystalline, cactus-type Ni(OH)₂@Mn₃O₄ nanocomposite of 10.10 nm average particle size. XPS analysis confirms that the synthesized materials consist mainly of Ni²⁺, Mn²⁺, and Mn³⁺. The antitumor activity of the nanocomposite was tested against a breast cancer (MCF-7) cell line. The results showed Ni(OH)₂@Mn₃O₄ nanocomposite possesses insignificant cytotoxicity. The cell-death percentage was 34% at a 100 ppm concentration of Ni(OH)₂@Mn₃O₄ nanocomposite. The obtained results imply that the synthesized nanocomposite could be suitable and safe for drug delivery and water treatment.