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Vitamin D deficiency in chronic obstructive pulmonary disease
Monica L L Mullin1, Stephen Milne1,2,3
1Division of Respiratory Medicine, The University of British Columbia.
Current Opinion in Pulmonary Medicine
|December 23, 2022
Summary
Vitamin D deficiency is common in chronic obstructive pulmonary disease (COPD). Supplementation may reduce exacerbations and improve quality of life, but more research is needed to confirm benefits.
Area of Science:
- Respiratory Medicine
- Nutritional Science
- Pulmonology
Background:
- Vitamin D plays a role in respiratory health.
- Vitamin D deficiency (VDD) is linked to adverse outcomes in chronic obstructive pulmonary disease (COPD).
- The prevalence of VDD in COPD patients may be underestimated.
Approach:
- This review synthesizes recent research on vitamin D's role in COPD.
- Focuses on biological and epidemiological evidence.
- Examines findings related to VDD and COPD exacerbations, functional capacity, and quality of life.
Key Points:
- Severe VDD treatment may decrease COPD exacerbations.
- Vitamin D supplementation might enhance functional capacity and quality of life in COPD patients.
- Current evidence does not strongly support vitamin D slowing lung function decline.
Conclusions:
- The causal relationship between vitamin D and COPD outcomes requires further investigation.
- The exact benefits of vitamin D supplementation in COPD are not yet fully established.
- High-quality randomized controlled trials are essential to clarify these associations.
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