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Updated: Aug 16, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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Study of left ventricular systolic dysfunction, left ventricular diastolic dysfunction and pulmonary hypertension in

Shivendra Singh1, Vikas Aggarwal2, Umesh Kumar Pandey2

  • 1Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.

Nefrologia
|December 23, 2022
PubMed

Insights

This study found that in chronic kidney disease (CKD) patients not on dialysis, pulmonary hypertension (PH) affects 12.2%, LV systolic dysfunction 15.6%, and LV diastolic dysfunction (LVDD) 43.65%. CKD duration and other factors predict these cardiovascular issues.

Area of Science:

  • Nephrology
  • Cardiology
  • Pulmonology

Background:

  • Cardiovascular diseases significantly increase morbidity and mortality in the chronic kidney disease (CKD) population.
  • Pulmonary hypertension (PH) is increasingly prevalent in CKD patients.
  • Left ventricular (LV) dysfunction, both systolic and diastolic, is a common complication in CKD.

Purpose of the Study:

  • To determine the prevalence of PH, LV systolic dysfunction, and LV diastolic dysfunction (LVDD) in CKD stages 3b-5 non-dialysis (ND) patients.
  • To identify predictors of PH, LV systolic dysfunction, and LVDD in this CKD population.

Main Methods:

  • A cross-sectional observational study included 378 CKD 3b-5ND patients aged ≥15 years.
  • Transthoracic 2D echocardiography was performed to assess PH (PASP >35mm Hg), LV systolic dysfunction (LVEF ≤50%), and LVDD (E/e' ratio >14).
  • Multivariate logistic regression was used to identify predictors.

Main Results:

  • Prevalence rates were: PH 12.2%, LV systolic dysfunction 15.6%, and LVDD 43.65%.
  • Predictors of PH included CKD duration, hemoglobin, serum 25-OH vitamin D, intact parathyroid hormone (iPTH), and serum albumin.
  • Predictors of LVDD were CKD duration and arterial hypertension; predictors of LV systolic dysfunction were eGFR, CKD duration, serum albumin, and urine protein.

Conclusions:

  • The study highlights a significant prevalence of PH and LV dysfunction in CKD 3b-5ND patients.
  • Identifying these predictors is crucial for risk stratification and management of cardiovascular complications in CKD.
Abstract

Keywords:
CKDDisfunción sistólica del VIHipertensión pulmonarLV systolic dysfunctionLVDDPulmonary hypertension

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