Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...

Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...

Stem Cell Niche

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cutibacterium acnes induce T cell extracellular traps with distinct proteome programs.

The Journal of investigative dermatology·2026

Same author

Dopamine signaling drives skin invasion by human-infective nematodes.

Nature communications·2025

Same author

Dynamics of Th1/Th17 responses and antimicrobial pathways in leprosy skin lesions.

The Journal of clinical investigation·2025

Same author

Insights into early acne pathogenesis: Exploring intercellular dynamics and key dysregulated genes.

Cell signaling·2025

Same author

Immune Activation and Glycolytic Responses to Cutibacterium acnes Cell Wall Polysaccharides.

The Journal of investigative dermatology·2025

Same author

Functional Dynamics of Dendritic Cells in Response to Cutibacteriumacnes Strains Associated with Healthy and Acne-Prone Skin.

The Journal of investigative dermatology·2025

Search research articles

Related Experiment Video

Updated: Aug 16, 2025

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells MSCs

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells MSCs

Published on: December 24, 2015

Do Mesenchymal Stem Cells Influence Keloid Recurrence?

Wanjala Ferdinand Nang'ole¹, Anzala Omu², Julius A Ogeng'o³

¹Department of Surgery, University of Nairobi, Nairobi, Kenya.

Stem Cells and Cloning : Advances and Applications

|December 26, 2022

Summary

Mesenchymal stem cells (MSCs) are more abundant in keloid tissue than normal skin. Recurrent keloids show significantly higher MSCs, suggesting a link between MSCs and keloid severity and recurrence.

Keywords:

keloids recurrence skin stem cells

More Related Videos

Author Spotlight: Advancements in iPSCs and Genetic Disease Research

Author Spotlight: Advancements in iPSCs and Genetic Disease Research

Published on: October 20, 2023

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

Published on: July 28, 2023

Related Experiment Videos

Last Updated: Aug 16, 2025

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells MSCs

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells MSCs

Published on: December 24, 2015

Author Spotlight: Advancements in iPSCs and Genetic Disease Research

Author Spotlight: Advancements in iPSCs and Genetic Disease Research

Published on: October 20, 2023

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

Published on: July 28, 2023

Area of Science:

Dermatology
Regenerative Medicine
Cell Biology

Background:

Mesenchymal stem cells (MSCs) are hypothesized as precursors for fibroblasts and myofibroblasts in keloids.
MSCs may represent a regenerative pool contributing to keloid formation.

Purpose of the Study:

To investigate the presence and density of MSCs in keloid tissue.
To determine if MSC levels correlate with keloid recurrence.

Main Methods:

A longitudinal prospective study comparing MSCs in keloid specimens and normal skin controls.
Statistical analysis included Student's t-test, chi-squared, and Fisher's exact tests.

Main Results:

Recurrent keloids exhibited a higher mean MSC density (841.4 MSCs/g) compared to non-recurrent keloids (578 MSCs/g) and normal skin (580 MSCs/g).
Keloid tissue generally showed a higher percentage of MSCs than normal skin.

Conclusions:

MSCs are present in higher percentages in keloids compared to normal skin.
Elevated MSC counts in recurrent keloids suggest a correlation with keloid disease severity and recurrence potential.