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Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
Published on: July 27, 2022
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Hydroxyapatite-bioglass nanocomposites: Structural, mechanical, and biological aspects
Olga Shikimaka1, Mihaela Bivol1, Bogdan A Sava2,3
1Institute of Applied Physics, 5 Academiei str., MD-2028, Chisinau, Republic of Moldova.
Beilstein Journal of Nanotechnology
|December 26, 2022
Summary
This study fabricated hydroxyapatite (HA) and bioglass nanocomposites, finding that precipitate HA (HAP) enhanced mechanical properties and reduced porosity compared to sol-gel HA (HAG). These factors influence biological performance and dissolution rates.
Area of Science:
- Materials Science
- Biomaterials Engineering
- Bioceramics
Background:
- Hydroxyapatite (HA) and boro-silico-phosphate bioglass are key biomaterials for bone regeneration.
- Controlling composite properties requires understanding the influence of HA source and processing parameters.
- Optimizing nanocomposite fabrication is crucial for enhanced biomedical applications.
Purpose of the Study:
- To fabricate and characterize hydroxyapatite (HA) and bioglass nanocomposites.
- To investigate the effects of HA type (precipitate HAP vs. sol-gel HAG), glass content, and sintering temperature on composite properties.
- To correlate microstructure, mechanical, chemical, and biological characteristics.
Main Methods:
- Fabrication of nanocomposites using precipitate hydroxyapatite (HAP) and sol-gel hydroxyapatite (HAG) with boro-silico-phosphate bioglass.
- Microstructural analysis, including porosity assessment.
- Evaluation of chemical, mechanical (microhardness), and biological properties (mineralization, cell viability).
- Systematic variation of HA type, glass content, and sintering temperature.
Main Results:
- All investigated factors (HA type, glass content, sintering temperature) significantly influenced composite microstructure and properties.
- HAP-based composites exhibited lower porosity than HAG-based ones.
- Porosity increased with higher bioglass content.
- Microhardness strongly correlated with porosity, with lower porosity yielding higher microhardness.
- Dissolution rates varied, impacting mineralization capability and cell viability.
Conclusions:
- The choice of hydroxyapatite source (HAP vs. HAG) critically affects nanocomposite microstructure and properties.
- Optimizing porosity through controlled fabrication is essential for enhancing mechanical and biological performance.
- These nanocomposites show potential for bone tissue engineering applications, with properties tunable by processing parameters.
