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Updated: Aug 16, 2025

Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
Published on: September 18, 2016
Sequential Cu(II)-Catalyzed Multicomponent C-N Coupling, Nucleophilic Addition, and Cyclization Cascade: A
Anchal Saxena1, Nayan Ghosh1,2
1Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, Uttar Pradesh, India.
Abstract:
Cascade or domino reactions serve as a powerful technique for the synthesis of complex organic scaffolds in one pot. Herein, a Cu(II)-catalyzed and silica gel-assisted multicomponent reaction (MCR) between bromoalkyne-tethered cyclohexadienones, amides, and water for the construction of hexahydrobenzofuran-3-carboxamide is developed. The reaction proceeds via a C-N coupling reaction followed by hydrative cyclization of ynamide intermediates. Notably, good to excellent diastereoselectivity is complementary of this reaction.
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