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Retroequatorial red retinal lesions in sickle cell anemia
M S Roy1, G P Rodgers, C T Noguchi
1National Eye Institute, Clinical Branch, Bethesda, Md.
Summary
Sickle cell anemia patients experienced unique retinal lesions that improved with nifedipine, a vasodilator. This suggests a new therapeutic approach for sickle cell retinopathy.
Area of Science:
- Ophthalmology
- Hematology
- Vascular Biology
Background:
- Sickle cell anemia is a genetic blood disorder.
- Retinopathy is a common complication of sickle cell anemia.
Observation:
- Two patients with sickle cell anemia presented with unusual red retinal lesions.
- One patient also had closure of retinal precapillary arterioles and capillaries.
Findings:
- Retinal lesions in both patients receded with nifedipine therapy.
- Nifedipine is a selective arteriolar vasodilator.
Implications:
- Nifedipine may be a potential treatment for sickle cell retinopathy.
- Further research into the pathogenesis of sickle cell retinopathy is warranted.
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