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Updated: Aug 15, 2025
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Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
Published on: May 10, 2022
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Group 2 innate lymphoid cells in human asthma
Arifumi Iwata1, Yosuke Toda1, Hiroki Furuya1
1Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Summary
Group 2 innate lymphoid cells (ILC2s) are crucial in Type 2-high asthma, driving airway inflammation. This review highlights their significant roles in human asthma pathogenesis, moving beyond murine models.
Area of Science:
- Immunology
- Pulmonology
- Allergy
Background:
- Asthma involves airway hyperresponsiveness, airflow limitation, and inflammation.
- Asthma is classified into Type 2-high and Type 2-low endotypes based on molecular mechanisms.
- Type 2-high asthma features Th2 cells and group 2 innate lymphoid cells (ILC2s) producing type 2 cytokines.
Purpose of the Study:
- To review the roles of ILC2s in asthma pathogenesis.
- To emphasize the accumulating evidence from human studies on ILC2s in asthma.
Main Methods:
- Review of existing literature on ILC2s in asthma.
- Focus on studies investigating ILC2s in human asthma.
Main Results:
- ILC2s are key players in Type 2-high asthma.
- ILC2s contribute to airway inflammation through type 2 cytokine production.
- Evidence supports ILC2 involvement in various asthma models, including human cases.
Conclusions:
- ILC2s are critical mediators in the pathogenesis of human asthma.
- Understanding ILC2 function is vital for developing targeted asthma therapies.
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