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Published on: December 2, 2022
Structurally diverse sulphur-containing amides from Glycosmis craibii with their potential antiproliferative
Shou-Yuan Wu1, Zi-Ming Chen1, Qi Zhou2
1Western Guangdong Characteristic Biology and Medicine Engineering and Research Center, School of Chemistry and Chemical Engineering, Lingnan Normal University, Zhanjiang 524000, China.
Abstract:
Fourteen new sulphur-containing amides, glycocramides A-N (1-14), as well as nine known analogues (15-23) were isolated and characterized from Glycosmis craibii Tanaka. The chemical structures of new sulphur-containing amides 1-14 were ambiguously elucidated by extensive spectroscopic methods, while the known compounds 15-23 were identified by the comparison of their experimental spectral data with those described data in the literatures. The antiproliferative effects of all isolated sulphur-containing amides were evaluated in vitro. As a result, part of sulphur-containing amides showed remarkable inhibitory effects against MGC-803 cell line with IC50 values ranging from 13.12 ± 0.10 to 20.03 ± 0.13 μM. These research results suggest that the sulphur-containing amides are potentially to be developed as a new natural anti-tumor drugs.
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