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Repeatability and reciprocity of the cone optoretinogram
R L Warner1, D H Brainard2, J I W Morgan1,3
1Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Biomedical Optics Express
|January 2, 2023
Summary
Cone optoretinography (ORG) noninvasively visualizes cone photoreceptor responses to light. This study confirms ORG repeatability in healthy adults, supporting its use as a biomarker for cone function and disease.
Area of Science:
- Ophthalmology
- Physiological optics
- Retinal imaging
Background:
- Optoretinography offers noninvasive visualization of cone photoreceptor physiological changes.
- Understanding cone optoretinogram (ORG) in healthy individuals is crucial for its application as a disease biomarker.
Purpose of the Study:
- To measure the population cone intensity optoretinogram in healthy adults.
- To assess the repeatability and reciprocity of the ORG across different stimulus conditions.
Main Methods:
- Healthy adult subjects underwent optoretinography.
- Visible stimuli with equal energy were used at various irradiance/duration combinations.
- Within- and between-session repeatability of the ORG was analyzed.
Main Results:
- The cone optoretinogram showed equivalent amplitudes for equal-energy stimuli.
- Good within-subject repeatability was observed.
- Individual differences in ORG responses among subjects were identified.
Conclusions:
- The cone optoretinogram is a repeatable measure in healthy adults.
- The findings support the potential of ORG as a biomarker for cone function.
- Individual variability in ORG responses warrants further investigation.
