Related Experiment Video
Updated: Aug 15, 2025
10:21
Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers
Published on: May 5, 2016
10.7K
All-fiber SPR microfluidic chip for GDF11 detection
1College of Electronic & Information Engineering, Chongqing Three Gorges University, Chongqing 404100, China.
Biomedical Optics Express
|January 2, 2023
Summary
This study presents a novel all-fiber Surface Plasmon Resonance (SPR) microfluidic chip for detecting low concentrations of growth differentiation factor 11 (GDF11). The innovative design offers sensitive, low-volume detection for potential wearable biosensing applications.
Area of Science:
- Biomedical Engineering
- Analytical Chemistry
- Optoelectronics
Background:
- Microfluidic detection of low-concentration cytokines like GDF11 typically involves integrated SPR sensing units.
- Existing methods face challenges in sensitivity and sample volume requirements for real-time monitoring.
Purpose of the Study:
- To develop a novel all-fiber SPR microfluidic chip for sensitive and efficient detection of GDF11.
- To overcome limitations of current cytokine detection techniques through an integrated fiber-optic approach.
Main Methods:
- Constructed an SPR sensing area on a D-shaped multimode fiber within a quartz tube to create a semi-cylindrical microfluidic channel.
- Applied surface sensitization and specific modification to the SPR sensing area for targeted GDF11 detection.
Main Results:
- Achieved a detection sensitivity of 1.38 nm/lg(g/mL) and a limit of detection of 0.52 pg/mL.
- Required only 0.4 µL of sample for a single detection, demonstrating low sample consumption.
Conclusions:
- The developed all-fiber SPR microfluidic chip offers flexible design, a compact structure, and minimal sample usage.
- This technology holds promise for wearable biosensors enabling real-time in vivo monitoring of trace cytokines.
