Inter-hemispheric Asymmetry Patterns in the ADHD Brain: A Neuroimaging Replication Study

Attention-deficit/ hyperactivity disorder (ADHD) is the most common neurodevelopment disorder in children, and many genetic markers have been linked to the behavioral phenotypes of this highly heritable disease. The neuroimaging correlates are similarly complex, with multiple combinations of structural and functional alterations associated with the disease presentations of hyperactivity and inattentiveness. Thus far, neuroimaging studies have provided mixed results in ADHD patients, particularly with respect to the laterality of findings. It is possible that hemispheric asymmetry differences may help reconcile the variability of these findings. We recently reported that inter-hemispheric asymmetry differences were more sensitive descriptors for identifying differences between ADHD and typically developing (TD) brains (n=849) across volumetric, morphometric, and white matter neuroimaging metrics. Here, we examined the replicability of these findings across a new data set (n=202) of TD and ADHD subjects at the time of diagnosis (medication naive) and after a six week course of either stimulant drugs, non-stimulant medications, or combination therapy. Our findings replicated our earlier work across a number of volumetric and white matter measures confirming that asymmetry is more robust at detecting differences between TD and ADHD brains. However, the effects of medication failed to produce significant alterations across either lateralized or symmetry measures. We suggest that the delay in brain volume maturation observed in ADHD youths may be hemisphere dependent. Future work may investigate the extent to which these inter-hemispheric asymmetry differences are causal or compensatory in nature.