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Immune-related adverse events: A bibliometric analysis
Shi-Tao Jiang1, Yao-Ge Liu1, Lei Zhang1
1Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
This bibliometric study analyzed 17 years of research on immune-related adverse events (irAEs) caused by immune checkpoint inhibitors (ICIs). The United States, Japan, and China lead in publications, with immunotherapy and nivolumab being key research topics.
Area of Science:
- Immunology
- Oncology
- Pharmacology
Background:
- Immune checkpoint inhibitors (ICIs) offer clinical benefits but can cause immune-related adverse events (irAEs).
- Understanding the research landscape of irAEs is crucial for managing these side effects.
Purpose of the Study:
- To conduct a bibliometric analysis of irAEs research.
- To map the knowledge structure and identify key trends in irAEs research over 17 years.
Main Methods:
- Data sourced from the Web of Science Core Collection (WoSCC).
- Bibliometric analysis using R package "Bibliometrix".
- Visualization tools like VOSviewer and CiteSpace were employed for co-authorship, keyword co-occurrence, and burst detection.
Main Results:
- A total of 3995 publications were analyzed.
- The United States, Japan, and China are the leading countries in irAEs research.
- The Journal for ImmunoTherapy of Cancer published the most articles. Keywords include "immune-related adverse events", "immune checkpoint inhibitors", "immunotherapy", and "nivolumab".
Conclusions:
- The study maps the foundational knowledge structure of irAEs research.
- Findings offer a comprehensive perspective on the future trajectory of irAEs research.
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