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Study of Changes in Serum Copper Level in Patients with Acute Myocardial Infarction
S Begum1, I Sultana, M R Faysal
1Dr Sumaiya Begum, Lecturer, Department of Biochemistry, Mymensingh Medical College (MMC), Mymensingh, Bangladesh;
Insights
Serum copper levels were significantly higher in patients with acute myocardial infarction (AMI) compared to healthy individuals. This finding suggests copper may play a role in heart attack-related free radical damage.
Area of Science:
- Biochemistry
- Cardiology
- Trace Element Research
Background:
- Acute myocardial infarction (AMI) is myocardial cell death due to ischemia, with risk factors including hypertension and high cholesterol.
- Coronary atherosclerosis is the primary cause of AMI.
- Micronutrients and trace elements are vital, and alterations can lead to cardiovascular diseases like coronary artery disease (CAD).
Purpose of the Study:
- To evaluate serum copper levels in patients diagnosed with acute myocardial infarction (AMI).
- To investigate the potential role of copper in free radical damage associated with myocardial reperfusion injury.
Main Methods:
- A case-control study involving 120 participants (60 AMI patients, 60 healthy controls).
- Serum copper levels were measured using standard biochemical assays.
- Data collected via pre-designed sheets after obtaining informed consent.
Main Results:
- Mean serum copper levels were significantly higher in the AMI group (146.49±23.52μg/dl) compared to the control group (105.44±24.15μg/dl).
- The difference in serum copper levels was statistically significant (p<0.05).
Conclusions:
- Serum copper levels are significantly elevated in patients with acute myocardial infarction.
- Monitoring serum copper may aid in managing free radical-induced reperfusion injury in AMI patients.
Abstract:
Acute myocardial infarction (AMI) commonly known as heart attack is defined pathologically as the irreversible death of myocardial cells caused by ischemia. Risk factors include high blood pressure, smoking, diabetes, lack of exercise, obesity, high blood cholesterol and excessive alcohol intake. The major cause of acute MI is coronary atherosclerosis with superimposed luminal thrombus, which accounts for more than 80% of all infarcts. Micronutrients and trace elements are very essential for normal functioning of the body. Even though they are required in very small amount, an alteration in the level of this element may lead to serious diseases like CAD and its consequences. The injury induced by reperfusion of the ischemic myocardium could result partially from the cytotoxic effects of oxygen free radicals. Copper is involved in several of the reactions in the protection from free radical damage. So, this study was designed to evaluate serum cupper level in AMI patients. This case-control study was conducted in the Department of Biochemistry, Mymensingh Medical College, Mymensingh, Bangladesh from July 2016 to June 2017. Total number of subjects was 120 in number. Among them 60 were diagnosed case of acute myocardial infarction and 60 were apparently healthy volunteers. Data were collected using pre-designed data collection sheets. After proper counseling informed written consent was taken from the study population. The study revealed that mean serum copper level was higher in case group as compared to control group. The mean±SD values of copper were 105.44±24.15μg/dl and 146.49±23.52μg/dl in control and case group respectively. The level of significance was 0.001 (p<0.05). After analyzing the results of the study it is concluded that serum copper level was significantly higher in Acute Myocardial Infarction patients than normal individuals. Therefore, estimation of serum copper level in AMI patients might be useful to take appropriate measure to prevent free radical induced reperfusion injury.
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