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Embryotoxic effects of sodium metavanadate administered to rats during organogenesis
J L Paternain1, J L Domingo, J M Llobet
1Departamento de Bioquímica, Facultad de Medicina, Universidad de Barcelona, Reus/Tarragona, Spain.
Revista Espanola De Fisiologia
|June 1, 1987
Abstract:
Pregnant Sprague-Dawley rats were given orally a daily dose of 0, 5, 10 or 20 mg NaVO3/kg from the sixth through the fourteenth day of pregnancy. Fetal examinations were performed on day 20 of gestation. Sodium metavanadate was neither embryolethal nor teratogenic in rats when administered orally at 20 mg/kg/day or lower. Nevertheless, this dose was embryotoxic.