Protocol for microwave-assisted synthesis of unsymmetrical azo dyes

Aromatic azo dyes bear immense commercial significance because of their extensive usage in the textile, paint, and food industries. With growing environmental concerns, developing alternative greener approaches for the synthesis of azo dyes is crucial. Herein, we describe a metal-free, microwave (MW)-assisted protocol for rapid access to a large variety of unsymmetrical azo dyes by coupling nitroarenes and aromatic amines. After MW-assisted coupling, the azo dyes are then isolated by precipitation followed by recrystallization to obtain pure azo dyes. For complete details on the use and execution of this protocol, please refer to Thakuri et al. (2022).¹.