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Melatonin in different food samples: Recent update on distribution, bioactivities, pretreatment and analysis
Xin-Yue Zhang1, Yuan Zhang2, Yu Zhou3
1School of Pharmacy, China Medical University, Shenyang 110122, China; Department of Clinical Pharmacy & Pharmacy Administration, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Food Research International (Ottawa, Ont.)
|January 3, 2023
Summary
Accurate detection of melatonin (MLT) in food is challenging due to its properties and trace levels. This review details advanced extraction and analysis methods to ensure MLT quality and safety.
Area of Science:
- Food Science
- Analytical Chemistry
- Biochemistry
Background:
- Melatonin (MLT) is vital for physiological functions and metabolic processes.
- Increasing MLT market share necessitates addressing quality control and application issues.
- MLT's photosensitivity, oxidation, and trace levels complicate accurate detection.
Purpose of the Study:
- To review MLT distribution and bioactivities.
- To provide a comprehensive overview of MLT pretreatment and analysis methods in food samples since 2010.
- To compare the advantages and disadvantages of various techniques and prospect future trends.
Main Methods:
- Review of literature on MLT extraction and detection methods.
- Analysis of traditional and novel pretreatment techniques (e.g., SPE, QuEChERS, MEPS, SPME, LPME).
- Evaluation of analytical methods including LC, GC, CE, and sensors.
Main Results:
- Identified various effective pretreatment techniques for MLT extraction.
- Compared different analytical methodologies for MLT quantification.
- Highlighted the challenges and advancements in MLT detection methodologies.
Conclusions:
- Precise, sensitive, and stable extraction and detection methods are crucial for MLT.
- Novel techniques offer improved performance for MLT analysis in food.
- Continued development in analytical methods is essential for ensuring MLT quality and safety.
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