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Updated: Aug 15, 2025

Murine Lymphocyte Labeling by 64Cu-Antibody Receptor Targeting for In Vivo Cell Trafficking by PET/CT
Published on: April 29, 2017
Highly inert Cu(II) complexes of C-aryl bifunctional cyclam-picolinates with remarkable 64Cu-labelling and
Julie Pineau1, Luís M P Lima2, Marie M Le Roy1
1Univ Brest, CEMCA, UMR CNRS 6521, 6 Av. Victor le Gorgeu, Brest 29200, France. nathalie.lebris@univ-brest.fr.
Abstract:
Cyclam-picolinate chelators were functionalized via click chemistry with an additional carboxyl group for subsequent bioconjugation to antibodies or for the modification of the overall charge of the corresponding 64Cu-radiocomplexes. The C-aryl functionalization strategy developed here preserves the chemical properties of the radiocomplexes whilst deeply enhancing their applications within nuclear medicine.
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