High-valent Cu(III)-CF₃ compound-mediated esterification reaction

Cu(III)-CF₃ compounds are reported herein as novel coupling reagents to mediate ester synthesis from carboxyl acids and alcohols/phenols. Carboxylic acids are transformed to trifluoromethyl ester and acyl fluoride activated species that interact with each other. The broad substrate scope and late-stage application of this method are demonstrated. This study opens up new opportunities to develop interesting reactions using Cu(III)-CF₃ compounds without transferring a CF₃ group to the products.