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Use of antibiotics in Paediatric Primary Health Care before and during the COVID-19 pandemic
David Pérez Solís1, Constanza Gómez de Oña2, María Luisa Nicieza García3
1Servicio de Pediatría, Hospital Universitario San Agustín, Avilés, Spain.
Insights
Antibiotic use in children in Asturias significantly decreased from 2014 to 2021, with a notable drop during the COVID-19 pandemic. This trend highlights changes in pediatric antimicrobial consumption patterns.
Area of Science:
- Pediatrics
- Infectious Diseases
- Public Health
Background:
- High antibiotic consumption in Spain, particularly among children, contributes to antimicrobial resistance.
- Understanding trends in pediatric antibiotic use is crucial for public health strategies.
Purpose of the Study:
- To analyze the evolution of antibiotic consumption in the pediatric population of Asturias, Spain, from 2014 to 2021.
- To evaluate the impact of the COVID-19 pandemic on pediatric antibiotic use.
Main Methods:
- Retrospective, observational study using data on systemic antibacterial agents dispensed via official prescriptions.
- Data collected for children under 14 years in Primary Health Care from 2014 to 2021.
- Antibiotic consumption measured in Defined Daily Doses (DDD) per 1000 inhabitants per day (DID).
Main Results:
- Antibiotic consumption rate decreased from 13.9 DID in 2014 to 4.0 DID in 2021, with an inflection point in 2019.
- A significant drop of 47.1% in antibiotic use occurred between 2019 and 2020, coinciding with the COVID-19 pandemic.
- Prevalence of antibiotic use fell from 39.9% in 2014 to 17.5% in 2021.
Conclusions:
- Pediatric antibiotic consumption in Asturias dramatically decreased in 2020, aligning with the COVID-19 pandemic.
- Continued monitoring of antimicrobial usage indicators is necessary to determine if these changes persist.
- The study underscores the significant impact of the pandemic on prescribing behaviors in pediatric primary care.
Introduction:
Consumption of antibiotics is high in Spain, primarily in children. Excessive use of then contributes to the development of antimicrobial resistance. The aim of our study is to analyse the evolution of antibiotic consumption at the Primary Health Care in the paediatric population of Asturias, Spain, from 2014 to 2021, and to evaluate the impact of COVID-19 pandemic on it.
Methods:
Retrospective and observational study using data about antibacterial agents for systemic use dispensed for official prescriptions to children under 14 years in Primary Care. Antibiotic consumption is expressed as defined daily dose (DDD) per 1000 inhabitants per day (DID).
Results:
The antibiotic consumption rate dropped from 13.9 DID in 2014 to 4.0 in 2021 (β=-1,42, p=0,002), with and inflection point in 2019. From 2019 to 2020 antibiotic use dropped by 47.1%. Antibiotic consumption remained very low from April 2020 to September 2021, and then moderately increased from October 2021. Prevalence of antibiotic use dropped from 39.9% in 2014 to 17.5% in 2021 (β=-3,64, p=0,006). Relative consumption of amoxicillin/clavulanic acid decreased, while those of amoxiciline and third-generation cephalosporins increased.
Conclusions:
Paediatric antibiotic consumption collapsed in Asturias in 2020, coinciding with COVID-19 pandemic. Monitoring of antimicrobial usage indicators will allow to check if these changes are sustained over time.
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