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Updated: Oct 25, 2026

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
Published on: October 12, 2018
Vulvar infection caused by Histoplasma capsulatum: case report and literature review
Fátima Vioque1, Montserrat Sevillano2, Daniel Tena1
1Sección de Microbiología, Hospital Universitario de Guadalajara, Spain.
Introduction:
Histoplasmosis is a systemic mycosis caused by Histoplasma capsulatum. Genital involvement is exceptional and has not been previously reported in Spain.
Methods:
We report a case of vulvar infection by H. capsulatum and review the literature to identify additional cases.
Results:
Four cases of vulvar histoplasmosis were identified, including the present one. All occurred in immunocompromised patients, mostly with HIV infection, and presented as vulvar lesions suggestive of neoplasia or sexually transmitted infections. In our case, a 38-year-old woman with advanced human immunodeficiency virus (HIV) infection, presented with a lesion suggestive of carcinoma. The diagnosis of histoplasmosis was confirmed by histopathology, fungal culture and molecular techniques, identifying H. capsulatum var. duboisii. All cases received antifungal therapy with favorable outcomes.
Conclusion:
Vulvar histoplasmosis is an exceptional entity that may mimic other diseases, particularly in immunocompromised patients, and should be considered in the differential diagnosis.
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