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Synthesis of cinchona urea polymers using Yamamoto coupling and their application to asymmetric reaction
Mohammad Farhadur Rahman1, Ikuhide Fujisawa1, Naoki Haraguchi1
1Applied Chemistry and Life Science, Toyohashi University of Technology, Toyohashi, Japan.
Abstract:
Cinchona urea compounds having 3,5-diiodophenyl moieties were subjected to Yamamoto coupling polymerization to afford the chiral urea polymers. These polymers showed high activities as heterogeneous catalysts in asymmetric Michael reactions comparable with those of the corresponding monomeric catalyst in solution systems. Furthermore, the polymeric catalysts are easily recovered from their reaction mixtures due to their insolubility and can be reused several times without loss of catalytic activity.
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