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Long-Term Retention Microbubbles with Three-Layer Structure for Floating Intravesical Instillation Delivery.

Qiurong Deng1, Junyi Xie1, Shuying Kong1

  • 1School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, China.

Small (Weinheim an Der Bergstrasse, Germany)
|January 12, 2023
PubMed
Summary

Researchers developed stable albumin bovine air microbubbles (BSA-MBs) for bladder cancer treatment. These microbubbles enhance drug retention in the bladder, improving therapeutic efficacy against bladder cancer.

Keywords:
air microbubblesbladder cancerdrug deliveryintravesical instillationsurface cross-linking-freeze drying

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Oncology

Background:

  • Intravesical instillation is crucial for bladder cancer therapy.
  • Rapid drug excretion via urination limits treatment efficacy.
  • Prolonging drug retention in the bladder is a key challenge.

Purpose of the Study:

  • To develop an effective drug delivery system for intravesical instillation.
  • To overcome rapid drug excretion and enhance therapeutic outcomes.
  • To create a stable, long-retention microbubble system for bladder cancer.

Main Methods:

  • A surface cross-linking-freeze drying strategy was employed.
  • Ultra-stable albumin bovine air microbubbles (BSA-MBs) were generated.
  • Doxorubicin (DOX)-loaded BSA-MBs (DOX-MBs) were prepared and characterized.

Main Results:

  • BSA-MBs demonstrated ultra-stability and long-term retention in the bladder.
  • The three-layer structure (membrane, drug layer, air core) facilitated floating and high drug loading.
  • DOX-MBs exhibited sustained drug release and potent anticancer efficacy in vivo.

Conclusions:

  • BSA-MBs represent a promising floating drug delivery system for intravesical instillation.
  • This strategy effectively overcomes drug excretion, enhancing bladder cancer treatment.
  • The developed microbubbles offer a novel approach for localized and sustained drug delivery.