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Updated: Aug 14, 2025

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Relationship of Arterial Stiffness and Central Hemodynamics With Cardiovascular Risk In Hypertension

Lin Jin1, Jianxiong Chen2, Mengjiao Zhang3

  • 1Department of Ultrasound, First Hospital of Shanxi Medical University, Taiyuan 030001, China.

American Journal of Hypertension
|January 16, 2023
PubMed

Insights

Central artery pulse pressure (CAPP) is a key indicator of cardiovascular risk in hypertension. Elevated CAPP values in uncontrolled hypertension may help identify individuals at higher risk for cardiovascular events.

Area of Science:

  • Cardiology
  • Public Health
  • Vascular Medicine

Background:

  • Hypertension is a growing public health concern.
  • Noninvasive assessment of central hemodynamics and artery stiffness are crucial for predicting cardiovascular disease (CVD).

Purpose of the Study:

  • To investigate the association between central hemodynamics, artery stiffness, and cardiovascular disease risk in a large cohort.
  • To identify predictors of high cardiovascular risk stratification.

Main Methods:

  • Assessed arterial velocity pulse index (AVI), arterial pressure-volume index (API), central systolic blood pressure (CSBP), central artery pulse pressure (CAPP), China-PAR, and Framingham cardiovascular risk score (FCVRS) in 4,311 participants (aged 20-79).
  • Utilized regression models and restrictive cubic spline functions to analyze relationships between variables.

Main Results:

  • Uncontrolled hypertension group exhibited higher AVI, API, CSBP, and CAPP.
  • Central artery pulse pressure (CAPP) and hypertension subtypes were significant predictors of high cardiovascular risk.
  • CAPP showed a strong correlation with API and significant J-shaped relationships with China-PAR and FCVRS.

Conclusions:

  • Uncontrolled hypertension is linked to elevated CAPP, CSBP, API, AVI, and cardiovascular risk scores.
  • CAPP is independently associated with high cardiovascular risk stratification.
  • The J-shaped relationship between CAPP and CVD risk scores may aid in identifying high-risk individuals.
Abstract

Keywords:
arterial stiffnessblood pressurecardiovascular diseasecentral artery pulse pressurecentral pressurehypertensionrisk assessment

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