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Updated: Aug 14, 2025

Contrast-Enhanced Subharmonic Aided Pressure Estimation SHAPE Using Ultrasound Imaging with a Focus on Identifying Portal Hypertension

Contrast-Enhanced Subharmonic Aided Pressure Estimation SHAPE Using Ultrasound Imaging with a Focus on Identifying Portal Hypertension

Published on: December 5, 2020

Noninvasive Evaluation of Cardiac Chamber Pressures Using Subharmonic-Aided Pressure Estimation With Definity

Cara Esposito¹, Priscilla Machado¹, Maureen E McDonald²

¹Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

JACC. Cardiovascular Imaging

|January 17, 2023

Summary

Accurate noninvasive intracardiac pressure measurement is now possible using the subharmonic-aided pressure estimation (SHAPE) technique with Definity microbubbles. This method shows promising efficacy for clinical applications in cardiac imaging.

Keywords:

intracardiac pressures microbubbles noninvasive pressures subharmonic aided pressure estimation ultrasound contrast agents

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Last Updated: Aug 14, 2025

Contrast-Enhanced Subharmonic Aided Pressure Estimation SHAPE Using Ultrasound Imaging with a Focus on Identifying Portal Hypertension

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Published on: February 26, 2013

Area of Science:

Cardiology
Medical Imaging
Biomedical Engineering

Background:

Accurate noninvasive assessment of intracardiac pressures remains a significant challenge in cardiac imaging.
Current methods often require invasive procedures, posing risks to patients.

Purpose of the Study:

To evaluate the accuracy of the subharmonic-aided pressure estimation (SHAPE) technique using contrast microbubbles for noninvasive intracardiac pressure measurement.
To determine if the errors in pressure measurements are less than 5 mm Hg.

Main Methods:

A clinical trial involving patients undergoing heart catheterization.
Acquisition of SHAPE data synchronously with invasive pressure catheter data.
Utilizing Definity microbubbles and a validated SHAPE interface for data collection.

Main Results:

Mean absolute errors for left ventricular diastolic pressures were 2.9 ± 2.0 mm Hg and 1.7 ± 1.2 mm Hg.
Mean absolute error for right ventricular systolic pressure was 2.2 ± 1.5 mm Hg.
Two minor adverse events occurred during microbubble infusion, both resolved.

Conclusions:

The SHAPE technique with Definity microbubbles demonstrates encouraging efficacy for accurate noninvasive intracardiac pressure measurement.
This technique offers a promising noninvasive alternative for assessing cardiac pressures.