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Related Experiment Video

Updated: Jul 16, 2026

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

Histopathological Variants of Cutaneous Neurofibroma: A Compendious Review.

Neha S Nagrani¹, Jag Bhawan¹

¹Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, Boston, MA 02118-2415, USA.

Dermatopathology (Basel, Switzerland)

|January 17, 2023

Summary

This review details rare histopathological variants of cutaneous neurofibroma. Recognizing these unusual features aids dermatopathologists in accurate diagnosis and avoids misinterpretation of benign neural neoplasms.

Keywords:

classification cutaneous neurofibroma histopathological variants

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Area of Science:

Dermatopathology
Surgical Pathology
Oncology

Background:

Histopathological variants of neurofibroma were first described in 1994.
Numerous case reports have since detailed unusual histologic features of neurofibroma.
Some variants have defined criteria, while others are classified as benign neural neoplasms.

Purpose of the Study:

To review and summarize novel and unusual histopathological variants of cutaneous neurofibroma.
To highlight features that may cause diagnostic challenges for dermatopathologists.
To provide a comprehensive overview based on existing literature and clinical practice.

Main Methods:

Literature review of published case reports and studies on neurofibroma variants.
Inclusion of unusual variants encountered in the authors' dermatopathology practice.
Synthesis of information to categorize and describe distinct histopathological features.

Main Results:

Identification and description of various unusual histopathological variants of cutaneous neurofibroma.
Discussion of features that can mimic other neoplasms or lead to diagnostic uncertainty.
Consolidation of knowledge regarding the spectrum of neurofibroma histopathology.

Conclusions:

Awareness of rare histopathological variants is crucial for accurate diagnosis of cutaneous neurofibroma.
This review aims to improve diagnostic confidence and reduce misinterpretation of benign neural neoplasms.
Understanding these variants is essential for dermatopathologists managing skin tumors.