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Published on: April 23, 2012
Macrostines A and B: Tetracyclic fisicoccane from the fungus Periconia macrospinosa WTG-10
Bing-Xian Li1, Yan Shu1, Sheng-Qi Zhang1
1Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, People's Republic of China.
Abstract:
Two previous unreported fusicoccane diterpenoids macrostines A and B, together with seven known compounds were isolated from an extract of the fungus Periconia macrospinosa WTG-10. Their structures were elucidated by detailed analysis of spectroscopic data, NMR calculations with DP4+, and their absolute configurations were further determined by quantum chemical calculations of ECD spectra or X-crystallography. Macrostines A and B showed no cytotoxicity, antimicrobial activity and inhibitory effect on nitric oxide production in LPS-activated RAW264.7 macrophages. Compound 9 showed moderate activity against Bacillus subtilis.
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Fungal Group Zygomycota
Fungal Phylum Microsporidia
Fungal Phylum Ascomycota
Bacterial Phylum Actinobacteria
Fungal Phylum Basidiomycota
Bacterial Phylum Planctomycetes

