Jove
Visualize
Contact Us

Related Concept Videos

Diencephalon: Thalamus and Information Relay01:27

Diencephalon: Thalamus and Information Relay

1.8K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is  a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
1.8K
Vision01:24

Vision

54.7K
Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
54.7K
Visual System01:26

Visual System

642
Light enters the eye through the cornea, a transparent, dome-shaped surface covering the surface of the eyeball that helps to direct and focus incoming light. This light is then channeled toward the pupil, an adjustable opening whose size is controlled by the iris. The iris, a pigmented muscle, regulates the amount of light entering the eye by contracting or dilating the pupil, thereby ensuring optimal light levels for clear vision.
Once through the pupil, the light passes through the lens, a...
642
Motor and Sensory Areas of the Cortex01:14

Motor and Sensory Areas of the Cortex

4.2K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Logic of Thalamic Inputs onto the Molecular Taxonomy of Cortical Neurons Reveals a Visual Hierarchy.

bioRxiv : the preprint server for biology·2026
Same author

A paradigm for skilled forelimb reaching by head-restrained mice.

bioRxiv : the preprint server for biology·2026
Same author

Vision shapes neural maps of space through an ancient midbrain pathway.

bioRxiv : the preprint server for biology·2026
Same author

Inter- and intrahemispheric sources of vestibular signals to V1.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

A Scalable Fishbone Nanowire Array (FINE) for 3D Quasi-Intracellular Recording in Intact Brains.

Advanced materials (Deerfield Beach, Fla.)·2025
Same author

Striatum supports fast learning but not memory recall.

Nature·2025
Same journal

Vestibular function drives gaze stability in locomoting macaques.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Region- and layer-specific glutamatergic synapse development in the nascent cortical hierarchy.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Endogenous peptide derived from c-Cbl-associated protein counteracts its inhibitory effect on enteric neural crest cell colonization in Hirschsprung disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Drowsiness alters the neural dynamics but not the core computations of multisensory integration.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

A Matter of Parameters: Tailored Transcranial Focused Ultrasound Enhances Cortico-Thalamo-Cortical Circuit Resonance.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Proactive visual and motor prioritization differentially scale with cue reliability.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Aug 14, 2025

State-Dependency Effects on TMS: A Look at Motive Phosphene Behavior
12:38

State-Dependency Effects on TMS: A Look at Motive Phosphene Behavior

Published on: December 28, 2010

10.6K

Brain State-Dependent Modulation of Thalamic Visual Processing by Cortico-Thalamic Feedback.

Kimberly Reinhold1,2,3, Arbora Resulaj2,3,4, Massimo Scanziani2,3,4

  • 1Neurosciences Graduate Program, University of California San Diego, La Jolla, 92093, California kimberly_reinhold@hms.harvard.edu.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|January 18, 2023
PubMed
Summary
This summary is machine-generated.

Brain state significantly influences how the brain processes visual information. Cortico-thalamic feedback is crucial for these state-dependent changes in the dorsolateral geniculate nucleus (dLGN) responses to visual stimuli.

Keywords:
behavioral statecortico-thalamic feedbackdLGNmouseprimary visual cortexvisual processing

More Related Videos

Modification of a Colliculo-thalamocortical Mouse Brain Slice, Incorporating 3-D printing of Chamber Components and Multi-scale Optical Imaging
06:05

Modification of a Colliculo-thalamocortical Mouse Brain Slice, Incorporating 3-D printing of Chamber Components and Multi-scale Optical Imaging

Published on: September 18, 2015

8.4K
Extracting Visual Evoked Potentials from EEG Data Recorded During fMRI-guided Transcranial Magnetic Stimulation
09:36

Extracting Visual Evoked Potentials from EEG Data Recorded During fMRI-guided Transcranial Magnetic Stimulation

Published on: May 12, 2014

13.9K

Related Experiment Videos

Last Updated: Aug 14, 2025

State-Dependency Effects on TMS: A Look at Motive Phosphene Behavior
12:38

State-Dependency Effects on TMS: A Look at Motive Phosphene Behavior

Published on: December 28, 2010

10.6K
Modification of a Colliculo-thalamocortical Mouse Brain Slice, Incorporating 3-D printing of Chamber Components and Multi-scale Optical Imaging
06:05

Modification of a Colliculo-thalamocortical Mouse Brain Slice, Incorporating 3-D printing of Chamber Components and Multi-scale Optical Imaging

Published on: September 18, 2015

8.4K
Extracting Visual Evoked Potentials from EEG Data Recorded During fMRI-guided Transcranial Magnetic Stimulation
09:36

Extracting Visual Evoked Potentials from EEG Data Recorded During fMRI-guided Transcranial Magnetic Stimulation

Published on: May 12, 2014

13.9K

Area of Science:

  • Neuroscience
  • Visual Processing
  • Sensory Systems

Background:

  • Mammalian brain state modulates sensory processing, even at early stages like the dorsolateral geniculate nucleus (dLGN).
  • dLGN neurons show altered responses to visual stimuli based on behavioral state (e.g., alert vs. quiescent).
  • The role of visual cortex feedback in these state-dependent dLGN responses remains unclear.

Purpose of the Study:

  • To investigate the contribution of cortico-thalamic feedback to state-dependent visual processing in the dLGN.
  • To determine if feedback influences responses to temporal and spatial visual features.

Main Methods:

  • Utilized male and female mice models.
  • Employed silencing of cortico-thalamic feedback pathways.
  • Recorded neural responses in the dLGN to visual stimuli.

Main Results:

  • Silencing cortico-thalamic feedback significantly diminished state-dependent differences in dLGN neuronal responses.
  • This effect was observed for both temporal and spatial aspects of visual stimuli.
  • Cortico-thalamic feedback is essential for modulating dLGN responses based on brain state.

Conclusions:

  • State-dependent shifts in visual processing at the dLGN rely on feedback from the visual cortex.
  • Cortico-thalamic feedback plays a critical role in integrating behavioral state with early visual information processing.