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Clinician's dilemma: Naproxen-induced liver injury
Shruti Sharma1, Akshi Sharma2, Mukesh Surya3
1Department of Pediatric Gastroenterology Cell, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.
Abstract:
Naproxen is a widely used nonsteroidal anti-inflammatory drug (NSAID) in pediatric population, used for mild-to-moderate pains, arthritis, and other immune-mediated disorders. It rarely causes clinically apparent liver injury in the adult population taking high doses of the drug over a prolonged period and is reported even rarer in pediatric population. We present a case of drug-induced liver injury (DILI) in a 13-year-old girl taking naproxen in therapeutic doses for juvenile rheumatoid arthritis. There was a complete recovery of liver function following discontinuation of naproxen therapy.
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