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TORC1 Signaling in Fungi: From Yeasts to Filamentous Fungi
Yuhua Wang1, Xi Zheng1, Guohong Li1
1State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming 650091, China.
Microorganisms
|January 21, 2023
Summary
Target of rapamycin complex 1 (TORC1) regulates fungal cell growth and development by integrating diverse signals. This review details TORC1
Area of Science:
- Molecular Biology
- Cell Biology
- Mycology
Background:
- Target of rapamycin complex 1 (TORC1) is a crucial signaling pathway kinase.
- TORC1 integrates environmental cues like nutrients and growth factors.
- TORC1 plays a vital role in cellular processes including growth, metabolism, and stress responses.
Purpose of the Study:
- To review the upstream and downstream signaling pathways of TORC1.
- To elucidate the multifaceted role of TORC1 in fungal biology.
Main Methods:
- Literature review of recent studies on TORC1 signaling in fungi.
- Analysis of published data on TORC1's regulatory mechanisms.
Main Results:
- TORC1 acts as a central hub, connecting nutrient availability to cell growth and development.
- TORC1 influences fungal morphology, protein synthesis, nutrient uptake, and metabolic pathways.
- Specific upstream signals and downstream effectors of TORC1 in fungi are identified.
Conclusions:
- TORC1 is indispensable for fungal adaptation and survival.
- Understanding TORC1 pathways provides insights into fungal physiology and potential therapeutic targets.
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